BBPA PET/CT in Patients With Malignant Tumors - EDITED

  • STATUS
    Recruiting
  • participants needed
    30
  • sponsor
    Peking Union Medical College Hospital
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Updated on 3 December 2024
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Summary

This study is an open-labeled phase II diagnostic clinical trial to explore the safety and clinical value of BBPA-PET/CT in suspected malignant tumor patients. The investigation regarding the clinical value of BBPA concerning the metabolic characteristics of BBPA in suspected malignant tumors. Quantitative features will be extracted to analysis the PET images. For patient who took surgery after multiple examination, histopathology, molecular pathology and LAT-1 immunohistochemistry will also be obtained.

Description

In this study, we utilized BBPA, a novel boron amino acid, which replaces the carboxyl group of 4-boronate phenylalanine (BPA) with a boron trifluoride group (-BF3) (-COOH), as a diagnostic molecule for PET imaging of brain tumors, is also a highly efficient boron carrier for BNCT. Preclinical studies suggested [18F]BBPA to be a pan-cancer probe that transmembrane transported through large neutral amino acid transporter type-1 (LAT-1). However more studies and evidence are warranted to investigate the clinical value of BBPA PET imaging in human.
This study aim to observe the safety of BBPA, and investigate the diagnostic value of BBPA in the patient with suspected malignant tumors. Patients who meet the eligibility criteria are included in clinical trials after fully communicating the condition, explaining the benefits and risks of clinical trials, clarifying the patient's willingness to include the clinical trial, and signing informed consent. The cohort number, BBPA administrative dose, imaging protocols are decided based on the investigators' preliminary data. The diagnosis and postexamination treatment are based on the recommended guideline, combined with the subject's own situation for standardized diagnosis and treatment

Details
Condition Malignant Tumors
Age 18years or above
Treatment BBPA PET examination
Clinical Study IdentifierNCT05987098
SponsorPeking Union Medical College Hospital
Last Modified on3 December 2024

Eligibility

 Yes No Not Sure

Inclusion Criteria

Have suspected diagnosis of brain tumors, based on clinical performance and imaging results
Meet the indications for PET examination, show a clear indication and no contraindications
Have a performance status of score ≥80 on KPS scale or score 0-1 points on ECOG scale, a relatively good general situation
Does not appear agonal stage, deep coma, over grade 2 major organ dysfunction (heart, lung, liver, kidney and other major organ include), acute or life-threatening status of infection
Be ≥ 18 years of age on day of signing informed consent
Be willing and able to understand the research content and provide written informed consent/assent for the trial

Exclusion Criteria

Have a history of imaging agent allergies
Does not meet the PET-CT scan sedation requirements, or there are contraindications for PET-CT examination
Be pregnant or breastfeeding, or expecting to conceive or father children within the projected duration of the trial
Unable to adhere strictly to protocol requirements
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