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Found 150 clinical trials
To Access the Safety and Effects of Intravenous Administration of AMX-818 Alone and in Combination With Pembrolizumab in Adult Participants With Locally Advanced or Metastatic HER2-Expressing Cancers

single agent and in combination with pembrolizumab in participants with HER2+ tumors across multiple tumor types. The study will be conducted in four parts:

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  • Part 1 (dose escalation): Single

    Accepts healthy volunteers
    • 0 views
    • 03 Dec, 2024
    • 10 locations
    A Study of Amivantamab and FOLFIRI Versus Cetuximab/Bevacizumab and FOLFIRI in Participants With KRAS/NRAS and BRAF Wild-type Colorectal Cancer Who Have Previously Received Chemotherapy

    to participants with Kirsten rat sarcoma viral oncogene/ neuroblastoma RAS viral oncogene homolog (KRAS/ NRAS) and v-raf murine sarcoma viral oncogene homolog B (BRAF) wild-type recurrent, unresectable

    • 0 views
    • 13 Feb, 2025
    • 54 locations
    A First-in-human, Dose Escalation and Dose Expansion Study of SAR445877 in Adult Participants With Advanced Solid Tumors

    participants aged at least 18 years with advanced unresectable or metastatic solid tumors. The study will include 2 parts: A dose escalation Part 1: for finding the therapeutic dose(s) of

    • 0 views
    • 03 Dec, 2024
    • 10 locations
    A Study Evaluating Safety and Therapeutic Activity of THOR-707 in Adult Subjects With Advanced or Metastatic Solid Tumors (THOR-707-101)

    THOR-707 as a single agent and as a combination therapy (Cohorts A, B, C, D, and G) Evaluate preliminary anti-tumor activity of THOR-707 as a single agent by determination of the objective

    cancer
    measurable disease
    EGFR
    colon cancer
    combination therapy
    • 0 views
    • 03 Dec, 2024
    • 15 locations
    Tusamitamab Ravtansine (SAR408701) in Combination With Pembrolizumab and Tusamitamab Ravtansine (SAR408701) in Combination With Pembrolizumab and Platinum-based Chemotherapy With or Without Pemetrexed in Patients With NSQ NSCLC (CARMEN-LC05)

    >

    Secondary Objectives:

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  • To assess the safety and tolerability of several DLs (if applicable) of tusamitamab ravtansine in combination with pembrolizumab and of 1 DL of tusamitamab

    • 0 views
    • 03 Dec, 2024
    • 27 locations
    International Treatment-extension Study in Adult Participants With Multiple Myeloma and Who Have Derived Clinical Benefit From Isatuximab

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  • This is a multi-center, open-label, Phase 2 treatment extension study in patients with multiple myeloma who are still benefitting from isatuximab based therapy following completion of a

    lenalidomide
    dexamethasone
    • 0 views
    • 03 Jul, 2025
    • 23 locations
    • 0 views
    • 13 Feb, 2025
    • 11 locations
    • 0 views
    • 13 Feb, 2025
    • 11 locations
    • 0 views
    • 07 Jan, 2025
    • 25 locations